Article: Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice.
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Tamagnini F; Novelia J; Kerrigan TL; Brown JT; Tsaneva-Atanasova K; Randall AD
Front Cell Neurosci, 2015
Action potential properties of CA1 pyramidal neurons in hippocampal slices from 20 to 23 month old PDAPP mice and age-matched WT littermate controls.
|
WT n = 27 |
PDAPP n = 30 |
Property |
Average |
SEM |
Average |
SEM |
p |
AP_peak (mV) |
25.05 |
1.53 |
20.24 |
1.71 |
0.04 |
AP_width (ms) |
0.83 |
0.03 |
0.74 |
0.03 |
0.04 |
AP_thres (mV) |
-58.64 |
0.81 |
-58.46 |
0.90 |
0.88 |
AP_max_dvdt (Vs-1) |
371.43 |
17.43 |
335.21 |
15.73 |
0.13 |
AP_AHP (mV) |
2.46 |
0.28 |
4.62 |
0.80 |
0.02 |
Inferred neuron-electrophysiology data values